Uni.-Prof. Dr. Thomas Böttcher



University of Vienna

Faculty of Chemistry
Department of Biological Chemistry & Centre for Microbiology and Environmental Systems Science

Althanstr. 14
1090 Wien

Curriculum Vitae

since October 2020 Professor of Microbial Biochemistry, Faculty of Chemistry and Department of Microbiology and Ecosystem Science, University of Vienna.

2020 ERC-Consolidator Grant

2019 Manfred-Fuchs-Prize of the Heidelberg Academy of Sciences and Humanities

2015-2020 Elected member of “Die Junge Akademie” at the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW) and the German National Academy of Sciences Leopoldina

2014-2020 Research Group Leader at the Department of Chemistry and Research Fellow at the Zukunftskolleg, University of Konstanz, Germany

2014 Emmy Noether Grant of DFG

2011-2014 Postdoctoral Research (funded by a Leopoldina Research Fellowship), Laboratory of Jon Clardy, Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, USA

2011-2014 Science manager and associate of AVIRU GmbH

2010-2011 Project Leader of the EXIST transfer of research project AVIRU, anti-virulence drug development, funded by the Federal Ministry for Economic Affairs and Energy (BMWi)

2010 Co-founder of AVIRU GmbH, Munich, Germany

2010 Postdoctoral Research, Laboratory of Stephan Sieber, TU Munich, Germany

2010 Klaus Tschira Award for achievements in public understanding of science

2010 Award of the Munich University Society

2006-2009 Doctoral Thesis (funded by the German Academic Scholarship Foundation), Laboratory of Stephan Sieber, CIPSM & Department of Chemistry and Biochemistry, LMU Munich, Germany

2004-2007 Fellow of the German Academic Scholarship Foundation

2003-2006 Studies of Chemistry and Biochemistry, LMU Munich, Germany

born 1982 in Munich, Germany


Ausgewählte Publikationen und Vorträge

M. Jancheva, T. Böttcher (2021) A Metabolite of Pseudomonas Triggers Prophage-Selective Lysogenic to Lytic Conversion in Staphylococcus aureus. J. Am. Chem. Soc. 143(22): 8344-8351.

M. Prothiwa, V. Filz, S. Oehler, T. Böttcher (2021) Inhibiting quinolone biosynthesis of Burkholderia. Chem. Sci. 12: 6908-6912.

L. Peñalver, P. Schmid, D. Szamosvári, S. Schildknecht, C. Globisch, K. Sawade, C. Peter, T. Böttcher (2021) A ligand selection strategy identifies chemical probes targeting the proteases of SARS‐CoV‐2. Angew. Chem. Int. Ed. 60(12): 6799-6806.

A. Pawar, M. Basler, H. Goebel, G. Alvarez Salinas, M. Groettrup, T. Böttcher (2020) Competitive metabolite profiling of natural products reveals subunit specific inhibitors of the 20S proteasome. ACS Cent. Sci. 6 (2): 241-246.

D. Szamosvári, T. Schuhmacher, C. Hauck, T. Böttcher (2019) A thiochromenone antibiotic derived from Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis. Chem. Sci. 10: 6624-6628.

M. Prothiwa, F. Englmaier, T. Böttcher (2018) Competitive live-cell profiling strategy for discovering inhibitors of the quinolone biosynthesis of Pseudomonas aeruginosa. J. Am. Chem. Soc. 140 (43): 14019–14023.

D. Szamosvári, T. Böttcher (2017) An unsaturated quinolone N-oxide of Pseudomonas aeruginosa modulates growth and virulence of Staphylococcus aureus. Angewandte Chemie Int. Ed. 56(25): 7271-7275.

S. Rütschlin, S. Gunesch, T. Böttcher (2017) One Enzyme, Three Metabolites: Shewanella algae controls siderophore production via the cellular substrate pool. Cell Chem. Biol. 24(5): 598-605.